Article

Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 <sup>+</sup> T cells

2022-02-24

Abstract excerpt

<h4>ABSTRACT</h4> The interleukin 7 receptor ( IL7R ) is strongly associated with increased risk to develop multiple sclerosis (MS), an autoimmune disease of the central nervous system, and this association is likely driven by upregulation of the soluble isoform of IL7R (sIL7R). Expression of sIL7R is determined by exclusion of the alternative exon 6 from IL7R transcripts, and our previous work revealed that the...

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Literature Corpus work: b18d40f6-57e9-51d8-8252-691cddb260e0
DOI: 10.1101/2022.02.22.481529

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Antisense modulation of IL7R splicing to control sIL7R expression in human CD4 <sup>+</sup> T cellsDOI 10.1101/2022.02.22.481529Read

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