Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allele

8 Oct 2019

Abstract excerpt

Abstract IL-7 is a key factor in T cell immunity and common variants at IL7R, encoding its receptor, are associated with autoimmune disease susceptibility. IL7R mRNA is induced in stimulated monocytes, yet a function for IL7R in monocyte biology remains unexplored. Here we characterize genetic regulation of IL7R at the protein level in healthy individuals, and find that monocyte surface and soluble IL7R (sIL7R)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoimmune and Inflammatory Disorders Research
Share to Immune Cell Function and Interaction
Share to Immune cells in cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31594933
DOI: 10.1038/s41467-019-12393-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Context-specific regulation of surface and soluble IL7R expression by an autoimmune risk allelePMID 31594933Read ↗

Context-specific regulation of monocyte surface IL7R expression and soluble receptor secretion by a common autoimmune risk alleleSemantic proximity Read ↗

IL7RA genetic variants differentially affect IL-7Rα expression and alternative splicing: a role in autoimmune and infectious diseases?Semantic proximity Read ↗

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis.Semantic proximity Read ↗

Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis.Semantic proximity Read ↗

Variation in IL7R predisposes to sarcoid inflammation.Semantic proximity Read ↗

Soluble IL-7Rα/sCD127 in Health, Disease, and Its Potential Role as a Therapeutic AgentSemantic proximity Read ↗

Gene expression and genotyping studies implicate the interleukin 7 receptor in the pathogenesis of primary progressive multiple sclerosis.Semantic proximity Read ↗

Cytokine gene polymorphisms and human autoimmune disease in the era of genome-wide association studies.Semantic proximity Read ↗

IL7 Genetic Variation Predicts Immune-Related Adverse Events.Semantic proximity Read ↗

Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis.Semantic proximity Read ↗

Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.Semantic proximity Read ↗

CD127 imprints functional heterogeneity to diversify monocyte responses in human inflammatory diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.