Article
Cleavage and polyadenylation specificity factor 1 (CPSF1) regulates alternative splicing of interleukin 7 receptor (IL7R) exon 6.
RNA (New York, N.Y.) - 1 Jan 2013
Evsyukova Irina, Bradrick Shelton S, Gregory Simon G, Garcia-Blanco Mariano A
Abstract excerpt
Interleukin 7 receptor, IL7R, is expressed exclusively on cells of the lymphoid lineage, and its expression is crucial for the development and maintenance of T cells. Alternative splicing of IL7R exon 6 results in membrane-bound (exon 6 included) and soluble (exon 6 skipped) IL7R isoforms. Interestingly, the inclusion of exon 6 is affected by a single-nucleotide polymorphism associated with the risk of developing...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.