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Somatic mutations in human ageing: New insights from DNA sequencing and inherited mutations.

Ageing research reviews - 1 Apr 2024

Chatsirisupachai Kasit, de Magalhães João Pedro

Abstract excerpt

The accumulation of somatic mutations is a driver of cancer and has long been associated with ageing. Due to limitations in quantifying mutation burden with age in non-cancerous tissues, the impact of somatic mutations in other ageing phenotypes is unclear. Recent advances in DNA sequencing technologies have allowed the large-scale quantification of somatic mutations in ageing tissues. These studies have revealed...

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PMID: 38490496
DOI: 10.1016/j.arr.2024.102268

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