Article
Somatic mutation rates scale with lifespan across mammals.
Nature - 1 Apr 2022
Cagan Alex, Baez-Ortega Adrian, Brzozowska Natalia, Abascal Federico, Coorens Tim H H, Sanders Mathijs A, Lawson Andrew R J, Harvey Luke M R, Bhosle Shriram, Jones David, Alcantara Raul E, Butler Timothy M, Hooks Yvette, Roberts Kirsty, Anderson Elizabeth, Lunn Sharna, Flach Edmund, Spiro Simon, Januszczak Inez, Wrigglesworth Ethan, Jenkins Hannah, Dallas Tilly, Masters Nic, Perkins Matthew W, Deaville Robert, Druce Megan, Bogeska Ruzhica, Milsom Michael D, Neumann Björn, Gorman Frank, Constantino-Casas Fernando, Peachey Laura, Bochynska Diana, Smith Ewan St John, Gerstung Moritz, Campbell Peter J, Murchison Elizabeth P, Stratton Michael R, Martincorena Iñigo
Abstract excerpt
The rates and patterns of somatic mutation in normal tissues are largely unknown outside of humans1-7. Comparative analyses can shed light on the diversity of mutagenesis across species, and on long-standing hypotheses about the evolution of somatic mutation rates and their role in cancer and ageing. Here we performed whole-genome sequencing of 208 intestinal crypts from 56 individuals to study the landscape of...
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