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Article

Biological drivers of clinical phenotype in myelofibrosis.

Leukemia - 1 Feb 2023

Mascarenhas John, Gleitz Hélène F E, Chifotides Helen T, Harrison Claire N, Verstovsek Srdan, Vannucchi Alessandro Maria, Rampal Raajit K, Kiladjian Jean-Jacques, Vainchenker William, Hoffman Ronald, Schneider Rebekka K, List Alan F

Abstract excerpt

Myelofibrosis (MF) is a myeloproliferative disorder that exhibits considerable biological and clinical heterogeneity. At the two ends of the disease spectrum are the myelodepletive or cytopenic phenotype and the myeloproliferative phenotype. The cytopenic phenotype has a high prevalence in primary MF (PMF) and is characterized by low blood counts. The myeloproliferative phenotype is typically associated with...

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Identifiers

PMID: 36434065
DOI: 10.1038/s41375-022-01767-y
PMCID: PMC9898039

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