Article
ASXL1 mutations accelerate bone marrow fibrosis via EGR1-TNFA axis-mediated neoplastic fibrocyte generation in myeloproliferative neoplasms.
Haematologica - 1 May 2023
Shi Zhongxun, Liu Jinqin, Zhao Yingying, Yang Lin, Cai Yanan, Zhang Peihong, Xu Zefeng, Qin Tiejun, Qu Shiqiang, Pan Lijuan, Wu Junying, Yan Xin, Li Zexing, Zhang Wenjun, Yan Yiru, Huang Huijun, Huang Gang, Li Bing, Wu Xudong, Xiao Zhijian
Abstract excerpt
Apart from the central role of the activated JAK/STAT signaling pathway, ASXL1 mutations are the most recurrent additional mutations in myeloproliferative neoplasms and occur much more commonly in myelofibrosis than in essential thrombocythemia and polycythemia vera. However, the mechanism of the association with ASXL1 mutations and bone marrow fibrosis remains unknown. Here, integrating our own data from...
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