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Article

Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Apr 2011

Tefferi Ayalew, Vaidya Rakhee, Caramazza Domenica, Finke Christy, Lasho Terra, Pardanani Animesh

Abstract excerpt

PURPOSE: Abnormal cytokine expression accompanies myelofibrosis and might be a therapeutic target for Janus-associated kinase (JAK) inhibitor drugs. This study describes the spectrum of plasma cytokine abnormalities in primary myelofibrosis (PMF) and examines their phenotypic correlates and prognostic significance. PATIENTS AND METHODS: Patients included in this study were required to have archived plasma, bone...

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Source

Identifiers

PMID: 21300928
DOI: 10.1200/JCO.2010.32.9490

Genes

MIP
HGF
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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