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Article

Myelofibrosis biology and contemporary management.

British journal of haematology - 1 Oct 2020

Gangat Naseema, Tefferi Ayalew

Abstract excerpt

Myelofibrosis is an enigmatic myeloproliferative neoplasm, despite noteworthy strides in understanding its genetic underpinnings. Driver mutations involving JAK2, CALR or MPL in 90% of patients mediate constitutive JAK-STAT signaling which, in concert with epigenetic alterations (ASXL1, DNMT3A, SRSF2, EZH2, IDH1/2 mutations), play a fundamental role in disease pathogenesis. Aberrant immature megakaryocytes are a...

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PMID: 32196650
DOI: 10.1111/bjh.16576

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