Article

Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model

2023-04-28

Abstract excerpt

Missing heritability is a current problem in human genetics. I previously reported a method to estimate heritability of a polymorphism (h p 2 ) for a common disease without calculating the genetic variance under dominant and the recessive models. Here, I extended the method to the co-dominant model and carry out trial calculations of h p 2 . I also calculated h p 2 applying the allele distribution model originally...

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Literature Corpus work: b1748359-8a0a-57a6-a2fd-1c355760a151
DOI: 10.1101/2023.04.25.23289037

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