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Article

The heritability of human disease: estimation, uses and abuses.

Nature reviews. Genetics - 1 Feb 2013

Tenesa Albert, Haley Chris S

Abstract excerpt

Relatives provide the basic material for the study of inheritance of human disease. However, the methodologies for the estimation of heritability and the interpretation of the results have been controversial. The debate arises from the plethora of methods used, the validity of the methodological assumptions and the inconsistent and sometimes erroneous genetic interpretations made. We will discuss how to estimate...

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PMID: 23329114
DOI: 10.1038/nrg3377

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