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Article

Recessive/dominant model: Alternative choice in case-control-based genome-wide association studies.

PloS one - 1 Jan 2021

Liu Han-Ming, Zheng Jin-Ping, Yang Dan, Liu Zhao-Fa, Li Zi, Hu Zhen-Zhen, Li Ze-Nan

Abstract excerpt

An additive genetic model is usually employed in case-control-based genome-wide association studies. The model usually encodes "AA", "Aa" and "aa" ("a" represents the minor allele) as three different numbers, implying the contribution of genotype "Aa" to the phenotype is different from "AA" and "aa". From the perspective of biological phenomena, the coding is reasonable since the phenotypes of lives are not...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34288964
DOI: 10.1371/journal.pone.0254947
PMCID: PMC8294554

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