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Article

The mystery of missing heritability: Genetic interactions create phantom heritability.

Proceedings of the National Academy of Sciences of the United States of America - 24 Jan 2012

Zuk Or, Hechter Eliana, Sunyaev Shamil R, Lander Eric S

Abstract excerpt

Human genetics has been haunted by the mystery of "missing heritability" of common traits. Although studies have discovered >1,200 variants associated with common diseases and traits, these variants typically appear to explain only a minority of the heritability. The proportion of heritability explained by a set of variants is the ratio of (i) the heritability due to these variants (numerator), estimated directly...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22223662
DOI: 10.1073/pnas.1119675109
PMCID: PMC3268279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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