Contribution of rare variants to heritability of a disease is much greater than conventionally estimated: modification of allele distribution model.

Abstract excerpt

"Missing heritability" is a current problem in human genetics. I previously reported a method to estimate heritability of a polymorphism (hp2) for a common disease without calculating the genetic variance under dominant and the recessive models. Here, I extend the method to the co-dominant model and carry out trial calculations of hp2. I also calculate hp2 applying the allele distribution model originally...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alleles
• Share to Case-Control Studies
• Share to Gene Frequency