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Article

Copy number variations play important roles in heredity of common diseases: a novel method to calculate heritability of a polymorphism.

Scientific reports - 24 Nov 2015

Nagao Yoshiro

Abstract excerpt

"Missing heritability" in genome wide association studies, the failure to account for a considerable fraction of heritability by the variants detected, is a current puzzle in human genetics. For solving this puzzle the involvement of genetic variants like rare single nucleotide polymorphisms (SNPs) and copy number variations (CNVs) has been proposed. Many papers have published estimating the heritability of sets...

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PMID: 26599540
DOI: 10.1038/srep17156
PMCID: PMC4657159

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