The 'common disease-common variant' hypothesis and familial risks.

doi:10.1371/journal.pone.0002504

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Article

The 'common disease-common variant' hypothesis and familial risks.

PloS one - 18 Jun 2008

Hemminki Kari, Försti Asta, Bermejo Justo Lorenzo

Abstract excerpt

The recent large genotyping studies have identified a new repertoire of disease susceptibility loci of unknown function, characterized by high allele frequencies and low relative risks, lending support to the common disease-common variant (CDCV) hypothesis. The variants explain a much larger proportion of the disease etiology, measured by the population attributable fraction, than of the familial risk. We show...

Topics

Alleles
Genetic Predisposition to Disease
Humans
Polymorphism, Genetic

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Identifiers

PMID: 18560565
DOI: 10.1371/journal.pone.0002504
PMCID: PMC2423486

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