Article
The 'common disease-common variant' hypothesis and familial risks.
PloS one - 18 Jun 2008
Hemminki Kari, Försti Asta, Bermejo Justo Lorenzo
Abstract excerpt
The recent large genotyping studies have identified a new repertoire of disease susceptibility loci of unknown function, characterized by high allele frequencies and low relative risks, lending support to the common disease-common variant (CDCV) hypothesis. The variants explain a much larger proportion of the disease etiology, measured by the population attributable fraction, than of the familial risk. We show...
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