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Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in <i>Pseudomonas aeruginosa</i> of clinical origin

2024-02-02

Abstract excerpt

The siderophore-cephalosporin cefiderocol(FDC) presents a promising treatment option for carbapenem-resistant (CR) P. aeruginosa (PA). FDC circumvents traditional porin and efflux mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR ex...

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Literature Corpus work
81678f87-a3e9-57bd-a7be-08068eff9895
DOI
10.1101/2024.01.30.578008
Open publication

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Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in <i>Pseudomonas aeruginosa</i> of clinical originDOI 10.1101/2024.01.30.578008
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