Article
Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin.
Antimicrobial agents and chemotherapy - 7 Aug 2024
Egge Stephanie L, Rizvi Samie A, Simar Shelby R, Alcalde Manuel, Martinez Jose R W, Hanson Blake M, Dinh An Q, Baptista Rodrigo P, Tran Truc T, Shelburne Samuel A, Munita Jose M, Arias Cesar A, Hakki Morgan, Miller William R
Abstract excerpt
The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR) P. aeruginosa (PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR...
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