Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Understanding mechanisms of reduced cefiderocol susceptibility in pvdS and fecI mutants of Pseudomonas aeruginosa.

The Journal of antimicrobial chemotherapy - 19 Jan 2026

Yamano Yoshinori, Takemura Miki, Longshaw Christopher, DeJonge Boudewijn L M, Ishibashi Naoki, Ishii Ryuta, Miyagawa Dai, Nakamura Rio, Kuroiwa Miho, Ishioka Yoshino, Adachi Takumi, Rokushima Masatomo, Maki Hideki, Sato Takafumi

Abstract excerpt

OBJECTIVES: Understand how mutations upstream of pvdS and fecI in Pseudomonas aeruginosa PAO1 lead to reduced susceptibility to cefiderocol, a siderophore cephalosporin. MATERIALS AND METHODS: Whole-genome sequencing, gene complementation and inactivation, mRNA expression, siderophore quantification and supplementation were carried out with mutants that showed reduced susceptibility to cefiderocol. RESULTS:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bacterial Outer Membrane Proteins
Share to Cephalosporins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligopeptides

Share to Pseudomonas aeruginosa

Share to Siderophores

Share to Sigma Factor

Share to Whole Genome Sequencing

Source

Open in PubMed Open full text

Identifiers

PMID: 41614616
DOI: 10.1093/jac/dkag004
PMCID: PMC12856659

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Understanding mechanisms of reduced cefiderocol susceptibility in pvdS and fecI mutants of Pseudomonas aeruginosa.PMID 41614616Read ↗

Mechanisms involved in cefiderocol resistance in French <i>Pseudomonas aeruginosa</i> clinical strainsSemantic proximity Read ↗

In vitro dynamics and mechanisms of cefiderocol resistance development in wild-type, mutator and XDR Pseudomonas aeruginosaSemantic proximity Read ↗

Rapid development of cefiderocol resistance in a carbapenem-resistant Pseudomonas aeruginosa isolate associated with mutations in the pyoverdine biosynthesis pathway.Semantic proximity Read ↗

Impact of transferable β-lactamases and intrinsic AmpC amino acid substitutions on the activity of cefiderocol against wild-type and iron uptake-deficient mutants of Pseudomonas aeruginosaSemantic proximity Read ↗

Genetic basis of cefiderocol resistance in Acinetobacter baumannii: insights from functional genomics and clinical isolates.Semantic proximity Read ↗

Relationship of TonB-dependent receptors with susceptibility to cefiderocol in clinical isolates of Pseudomonas aeruginosaSemantic proximity Read ↗

Loss of the Ferripyochelin Receptor FptA Drives Reduced Cefiderocol Susceptibility and Impairs Fitness in <i>Pseudomonas aeruginosa</i> PA14Semantic proximity Read ↗

Influence of iron uptake systems on cefiderocol activity in <i>Escherichia coli</i> : at the crossroads of antibiotic resistance and virulenceSemantic proximity Read ↗

Mechanisms of Reduced Susceptibility to Cefiderocol Among Isolates from the CREDIBLE-CR and APEKS-NP Clinical TrialsSemantic proximity Read ↗

Genomic analysis reveals multi-level resistance network linking oxidative stress pathway mutations to cefiderocol resistance and clonal evolution in Klebsiella pneumoniae from the United Arab Emirates.Semantic proximity Read ↗

In vitro activity of cefiderocol in Pseudomonas aeruginosa isolates from people with cystic fibrosis recovered during three multicentre studies in Spain.Semantic proximity Read ↗

Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in Pseudomonas aeruginosa of clinical origin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.