Article

Type I IFN expression is inhibited during cell division by CDK4/6

2023-04-16

Abstract excerpt

<h4>Summary</h4> Cells are equipped to defend themselves from invading pathogens through sensors such as cGAS, which upon binding DNA induces type I interferon (IFN) expression. Whilst IFNs are crucial for limiting viral infection and activating adaptive immunity, uncontrolled production causes excessive inflammation and autoimmunity. cGAS binds DNA of both pathogenic and cellular origin and its activity is there...

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Literature Corpus work: b15676a9-56cb-507a-9aa5-ca73a3b8f609
DOI: 10.1101/2023.04.15.537049

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