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Targeting mitotic regulators in cancer as a strategy to enhance immune recognition

18 Oct 2023

Abstract excerpt

Eukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory responses driven by the immunogenic nature of cytoplasmic DNA. Cyclic GMP-AMP Synthase (cGAS) is the cytoplasmic dsDNA sensor, which upon activation of Stimulator of Interferon Genes (STING), mediates production of pro-inflammatory interferons (IFNs) and interferon stimulated genes (ISGs). However,...

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PMID: 37871511
DOI: 10.1016/j.dnarep.2023.103583

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