Article

Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillation

2023-03-12

Abstract excerpt

<h4>Summary</h4> Endolysosomes (EL) are known for their role in regulating both intracellular trafficking and proteostasis. EL help facilitate elimination of damaged membrane and cytosolic proteins, protein aggregates, membranous organelles and also play an important role in calcium signalling. Despite the importance of EL, their specific role in cardiovascular disease is not well understood. In particular, it’s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9afa9e03-fcf1-50d1-940e-00274d5fd108
DOI: 10.1101/2023.03.10.532119

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Compartmentalisation proteomics revealed endolysosomal protein network changes in a goat model of atrial fibrillationDOI 10.1101/2023.03.10.532119Read

Role of Autophagy in Proteostasis: Friend and Foe in Cardiac DiseasesSemantic proximity Read

Endoplasmic Reticulum Stress Is Associated With Autophagy and Cardiomyocyte Remodeling in Experimental and Human Atrial Fibrillation.Semantic proximity Read

Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation.Semantic proximity Read

Transcriptome and proteome mapping in the sheep atria reveal molecular featurets of atrial fibrillation progressionSemantic proximity Read

CEACAM1 Targets ABCA1 to Mediate Atrial Fibrillation via Lipophagy-Dependent FerroptosisSemantic proximity Read

The Role of Cardiolipin in Cardiovascular HealthSemantic proximity Read

Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac FunctionSemantic proximity Read

Heart failure, female sex and atrial fibrillation are the main drivers of human atrial cardiomyopathy: results from the CATCH ME consortiumSemantic proximity Read

Protein and Mitochondria Quality Control Mechanisms and Cardiac AgingSemantic proximity Read

Fibrosis in Arrhythmogenic Cardiomyopathy: The Phantom Thread in the Fibro-Adipose TissueSemantic proximity Read

Early atrial remodelling drives arrhythmia in Fabry DiseaseSemantic proximity Read

Atrial Proteomic Profiling Reveals a Switch Towards Profibrotic Gene Expression Program in CREM-IbΔC-X Mice with Persistent Atrial FibrillationSemantic proximity Read