Article

A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

2019-10-10

Abstract excerpt

A synthetic lethal effect arises when a cancer-associated change introduces a unique vulnerability to cancer cells that makes them unusually susceptible to a drug’s inhibitory activity. The synthetic lethal approach is attractive because it enables targeting of cancers harboring specific genomic alterations, the products of which may have proven refractory to direct targeting. An example is cancer driven by overex...

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Literature Corpus work: b151ac97-694a-5241-8587-9f16472e8725
DOI: 10.1101/801134

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