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Article

Synthetic lethal screens as a means to understand and treat MYC-driven cancers.

Cold Spring Harbor perspectives in medicine - 1 Mar 2014

Cermelli Silvia, Jang In Sock, Bernard Brady, Grandori Carla

Abstract excerpt

Although therapeutics against MYC could potentially be used against a wide range of human cancers, MYC-targeted therapies have proven difficult to develop. The convergence of breakthroughs in human genomics and in gene silencing using RNA interference (RNAi) have recently allowed functional interrogation of the genome and systematic identification of synthetic lethal interactions with hyperactive MYC. Here, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24591535
DOI: 10.1101/cshperspect.a014209
PMCID: PMC3935389

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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