Article
Development of small-molecule probes that selectively kill cells induced to express mutant RAS.
Bioorganic & medicinal chemistry letters - 15 Feb 2012
Weïwer Michel, Bittker Joshua A, Lewis Timothy A, Shimada Kenichi, Yang Wan Seok, MacPherson Lawrence, Dandapani Sivaraman, Palmer Michelle, Stockwell Brent R, Schreiber Stuart L, Munoz Benito
Abstract excerpt
Synthetic lethal screening is a chemical biology approach to identify small molecules that selectively kill oncogene-expressing cell lines with the goal of identifying pathways that provide specific targets against cancer cells. We performed a high-throughput screen of 303,282 compounds from the National Institutes of Health-Molecular Libraries Small Molecule Repository (NIH-MLSMR) against immortalized BJ...
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