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Article

Integrated genomic and pharmacological approaches to identify synthetic lethal genes as cancer therapeutic targets.

Current molecular medicine - 1 Dec 2008

Mizuarai Shinji, Irie Hiroki, Schmatz Dennis M, Kotani Hidehito

Abstract excerpt

Various types of cancers are generated through mutations or dysregulations of oncogenes/tumor suppressor genes involved in cell cycles and signaling transduction pathways. To identify cancer therapeutic targets whose inhibition selectively kills cancer cells, synthetic lethal screening is being developed to identify genes whose intervention suppresses tumor progression only when combined with the dysregulation of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19075675
DOI: 10.2174/156652408786733676

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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