Article

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism network

2020-02-20

Abstract excerpt

<h4>ABSTRACT</h4> Mechanisms-of-resistance to decitabine and 5-azacytidine, mainstay treatments for myeloid malignancies, require investigation and countermeasures. Both are nucleoside analog pro-drugs processed by pyrimidine metabolism into a nucleotide analog that depletes the key epigenetic regulator DNA methyltranseferase 1 (DNMT1). We report here that DNMT1 protein, although substantially depleted (~50%) in...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b12aa87b-c45c-5852-a08e-dbde61d77254
DOI: 10.1101/2020.02.20.958405

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Resistance to decitabine and 5-azacytidine emerges from adaptive responses of the pyrimidine metabolism networkDOI 10.1101/2020.02.20.958405Read

ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathwaysSemantic proximity Read

Hotspot DNMT3A mutations in Clonal Hematopoiesis and Acute Myeloid Leukemia sensitize cells to Azacytidine via viral mimicry responseSemantic proximity Read

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase InhibitionSemantic proximity Read

Key clinical observations after 5-azacytidine and decitabine treatment of myelodysplastic syndromes suggest practical solutions for better outcomesSemantic proximity Read

Macrophage-secreted Pyrimidine Metabolites Confer Chemotherapy Resistance in Acute Myeloid Leukemia (AML)Semantic proximity Read

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity Read

Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance roleSemantic proximity Read

The Emerging Role of Cytidine Deaminase in Human Diseases: A New Opportunity for Therapy?Semantic proximity Read

E2F1-Associated Purine Synthesis Pathway Is a Major Component of the MET-DNA Damage Response NetworkSemantic proximity Read

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity Read

Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemiaSemantic proximity Read

Equitoxic Doses of 5-Azacytidine and 5-Aza-2′Deoxycytidine Induce Diverse Immediate and Overlapping Heritable Changes in the TranscriptomeSemantic proximity Read