Article

Pan-cancer analysis of pyrimidine metabolism reveals signaling pathways connections with chemoresistance role

2023-12-08

Abstract excerpt

Deregulated nucleotide metabolism, and in particular increased pyrimidine metabolism (PyMet), has been shown to contribute to various pathological features of cancer including chemoresistance and epithelial-to-mesenchymal transition. However, cancer often encompasses complex signaling and metabolic pathway cascades for its progression, and understanding of these molecular regulatory processes in pyrimidine metabol...

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Literature Corpus work: 12aa8ebd-6150-5c73-a7d1-9f43d8b12a9c
DOI: 10.1101/2023.12.06.570388

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