Back to search

Article

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line

2022-02-03

Abstract excerpt

Azacytidine (AzaC) and decitabine (AzadC) are cytosine analogs that covalently trap DNA methyltransferases, which place the important epigenetic mark 5-methyl-2’-deoxycytidine by methylating 2’-deoxycytidine (dC) at the C5 position. AzaC and AzadC are used in the clinic as antimetabolites to treat myelodysplastic syndrome and acute myeloid leukemia and are explored against other types of cancer. Although their pri...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ec9cb7cf-6afa-5cd6-a8b6-8c9411ad6756
DOI
10.1101/2022.02.03.476906
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineDOI 10.1101/2022.02.03.476906
Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell lineSemantic proximity
A Comparison of Azacitidine and Decitabine Activities in Acute Myeloid Leukemia Cell LinesSemantic proximity
Epigenetic anti-cancer treatment with a stabilized carbocyclic Decitabine analogueSemantic proximity
Azacytidine causes complex DNA methylation responses in myeloid leukemiaSemantic proximity
A clinical-molecular update on azanucleoside-based therapy for the treatment of hematologic cancersSemantic proximity
Key clinical observations after 5-azacytidine and decitabine treatment of myelodysplastic syndromes suggest practical solutions for better outcomesSemantic proximity
Genomic impact of transient low-dose decitabine treatment on primary AML cellsSemantic proximity
Dissection of demethylation and toxicity induced gene expression changes after decitabine treatmentSemantic proximity
DNA Hypermethylation of Myeloid Cells, A Novel Therapeutic Target in MDS and AMLSemantic proximity
DNA methyltransferase inhibitors in acute myeloid leukemia: discovery, design and first therapeutic experiences.Semantic proximity
The use of hypomethylating agents in the treatment of hematologic malignanciesSemantic proximity
DNA Methyltransferase Inhibitors and their Therapeutic PotentialSemantic proximity
Select a neighboring publication to make it the new centre.