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ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways

4 Aug 2017

Abstract excerpt

Leukemia cells rely on two nucleotide biosynthetic pathways, de novo and salvage, to produce dNTPs for DNA replication. Here, using metabolomic, proteomic, and phosphoproteomic approaches, we show that inhibition of the replication stress sensing kinase ataxia telangiectasia and Rad3-related protein (ATR) reduces the output of both de novo and salvage pathways by regulating the activity of their respective...

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PMID: 28808226
DOI: 10.1038/s41467-017-00221-3

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