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Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemia

2026-03-16

Abstract excerpt

Acute lymphoblastic leukemia (ALL) exhibits marked genetic and metabolic heterogeneity that limits the efficacy of targeted therapies. Antimetabolite strategies remain central to ALL treatment, yet the mechanisms underlying differential drug sensitivity are incompletely defined. Here, we investigated the activity of the purine analog triciribine (TCN) across diverse ALL cellular models. We find that TCN exerts pot...

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Literature Corpus work
0d5f1c8d-2689-51ec-815c-20e6625b9f35
DOI
10.64898/2026.03.13.710465
Open publication

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Proteomic profiling reveals pleiotropic antimetabolite activity of triciribine in acute lymphoblastic leukemiaDOI 10.64898/2026.03.13.710465
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