Article

Defective Nucleotide Catabolism Defines a Subset of Cancers Sensitive to Purine Nucleoside Phosphorylase Inhibition

2019-10-29

Abstract excerpt

<h4>ABSTRACT</h4> Small molecule inhibitors of purine nucleoside phosphorylase (PNP) have been explored as a treatment strategy for leukemia and lymphoma, however, the determinants of response to this class of drugs are incompletely understood. PNP inhibitors impair cell proliferation by preventing catabolism of the nucleoside deoxyguanosine (dG) which induces toxic imbalances amongst intracellular deoxyribonucle...

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Literature Corpus work: 24e6f35c-2067-5313-afc7-2409aeecbef5
DOI: 10.1101/810093

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