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Article

Role of soluble epoxide hydrolase in age-related vascular cognitive decline.

Prostaglandins & other lipid mediators - 1 Oct 2014

Nelson Jonathan W, Young Jennifer M, Borkar Rohan N, Woltjer Randy L, Quinn Joseph F, Silbert Lisa C, Grafe Marjorie R, Alkayed Nabil J

Abstract excerpt

P450 eicosanoids are important regulators of the cerebral microcirculation, but their role in cerebral small vessel disease is unclear. We tested the hypothesis that vascular cognitive impairment (VCI) is linked to reduced cerebral microvascular eicosanoid signaling. We analyzed human brain tissue from individuals formerly enrolled in the Oregon Brain Aging Study, who had a history of cognitive impairment...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25277097
DOI: 10.1016/j.prostaglandins.2014.09.003
PMCID: PMC4254026

Genes

EPHX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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