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The evolutionarily conserved APP-Spastin cooperation regulates endolysosomal homeostasis and apoptotic cell degradation

2026-07-15

Abstract excerpt

Efferocytosis, the recognition, engulfment, and degradation of apoptotic cells by phagocytes, is essential for tissue homeostasis and development, and its failure contributes to chronic inflammation and neurodegeneration. The amyloid precursor protein (APP), a central pathogenic factor in Alzheimer’s disease, retains physiological functions independent of amyloid production that remain poorly understood. Here, we...

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Literature Corpus work
b0fca40c-bcb1-5aad-9f78-5af6b520f5ff
DOI
10.64898/2026.07.14.738573
Open publication

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The evolutionarily conserved APP-Spastin cooperation regulates endolysosomal homeostasis and apoptotic cell degradationDOI 10.64898/2026.07.14.738573
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