Article

Compartment Mismatch Produces Near-Perfect Apparent Discrimination in Blood-Referenced DNA-Methylation Classifiers: A Public-Cohort Reanalysis of Hematologic-Malignancy Series

2026-07-27

Abstract excerpt

<title>Abstract</title> <p> Background. Blood-based DNA-methylation classifiers are commonly validated by scoring publicly deposited disease cohorts against a healthy reference. Where the classifier is a deviation metric — the distance of a sample from a healthy baseline — it inherits the hematopoietic compartment of that baseline. Publicly deposited hematologic-malignancy series are heterogeneous in compartmen...

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Literature Corpus work: b0e58637-c255-5ed8-a8ed-eb97f8f04b91
DOI: 10.21203/rs.3.rs-10472780/v1

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Compartment Mismatch Produces Near-Perfect Apparent Discrimination in Blood-Referenced DNA-Methylation Classifiers: A Public-Cohort Reanalysis of Hematologic-Malignancy SeriesDOI 10.21203/rs.3.rs-10472780/v1Read

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