Article

IgG4 <sup>+</sup> plasma cell enrichment and λ-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary disease

2026-06-30

Abstract excerpt

<h4>Background</h4> This study aimed to elucidate B cell subset pathology in COPD, a poorly characterized area, with a focus on its similarities to and differences from classical autoimmune disorders. <h4>Methods</h4> The single-cell RNA-sequencing (scRNA-seq) data from COPD and autoimmune diseases were obtained from Gene Expression Omnibus (GEO) for comparative analyses of B cell subsets and functions via diffe...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1707b63-65db-595e-bbcb-813900907ef4
DOI: 10.64898/2026.06.25.734436

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

IgG4 <sup>+</sup> plasma cell enrichment and λ-chain-biased BCR remodeling drive low-grade autoimmunity in chronic obstructive pulmonary diseaseDOI 10.64898/2026.06.25.734436Read

Single-cell multi-omics show disruption of blood and airway T-cells in pulmonary long COVIDSemantic proximity Read

Single-cell transcriptome analysis and protein profiling reveal broad immune system activation in IgG4-related diseaseSemantic proximity Read

The landscape of T and B lymphocytes interaction and synergistic effects of Th1 and Th2 type response in the involved tissue of IgG4-RD revealed by single cell transcriptome analysisSemantic proximity Read

Peripheral Blood Single-Cell Sequencing Uncovers Common and Specific Immune Aberrations in Fibrotic Lung DiseasesSemantic proximity Read

The Single-Cell Immunogenomic Landscape of B and Plasma Cells in Early-Stage Lung AdenocarcinomaSemantic proximity Read

A spatial multi-omics atlas of the human lung reveals a novel gland-associated immune nicheSemantic proximity Read

AT2 Cell-Derived IgA Trapped by the Extracellular Matrix and Promoted Pulmonary FibrosisSemantic proximity Read

A spatial multi-omics atlas of the human lung reveals a novel immune cell survival nicheSemantic proximity Read

Spatial Transcriptomics Resolve an Emphysema-Specific Lymphoid Follicle B Cell Signature in Chronic Obstructive Pulmonary DiseaseSemantic proximity Read

Cytoimmunological Profile of Lower Airways in Post-COVID-19 Syndrome (PCS): Predictive Value of Bronchoalveolar LavageSemantic proximity Read

Comparative Network Analysis of Patients with Non-Small Cell Lung Cancer and Smokers for Representing Potential Therapeutic TargetsSemantic proximity Read

Integrated EVLP and single-cell profiling uncovers aberrant activation of tissue-resident lymphocytes and pro-fibrotic GZMK⁺ CD8 T cells in IPFSemantic proximity Read