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Single-cell RNA-sequencing reveals distinct immune cell subsets and signaling pathways in IgA nephropathy

1 Dec 2021

Abstract excerpt

BACKGROUND: IgA nephropathy (IgAN) is the most common primary glomerulonephritis globally. Increasing evidence suggests the importance of host immunity in the development of IgAN, but its dynamics during the early stage of IgAN are still largely unclear. RESULTS: Here we successfully resolved the early transcriptomic changes in immune cells of IgAN by conducting single-cell RNA-sequencing (scRNA-seq) with...

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Renal Diseases and Glomerulopathies
Single-cell and spatial transcriptomics
Vasculitis and related conditions

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34895340
DOI: 10.1186/s13578-021-00706-1

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