Article

Multi-step antibody class switching in a primary human response is restricted after <i>IGHG2</i> and dependent on B cell maturation stage

2025-05-08

Abstract excerpt

Class switch recombination (CSR) allows the formation of functionally specialized antibodies. Understanding of CSR dynamics is key for better design and prediction of vaccines to protect mucosal surfaces. To investigate CSR in a primary human immune response under a controlled setting, we sampled healthy volunteers without COVID-19 history every other day during the first three weeks after SARS-CoV-2 vaccination,...

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Literature Corpus work: 364c3fdf-e431-5a68-adf6-d5961776f978
DOI: 10.1101/2025.05.07.652638

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