Article

Deep mutational scanning reveals functional constraints and antigenic variability of Lassa virus glycoprotein complex

2024-02-06

Abstract excerpt

Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must account for the evolutionary variability of Lassa virus’s glycoprotein complex (GPC), which mediates viral entry into cells and is the target of neutralizing antibodies. To map the evolutionary space accessible to GPC,...

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Literature Corpus work: b0da4012-b2b9-54ff-935b-dc00fc8421a6
DOI: 10.1101/2024.02.05.579020

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