Deep mutational scanning of rabies glycoprotein defines mutational constraint and antibody-escape mutations

Abstract excerpt

Rabies virus causes nearly 60,000 human deaths annually. Antibodies that target the rabies glycoprotein (G) are being developed as post-exposure prophylactics, but mutations in G can render such antibodies ineffective. Here, we use pseudovirus deep mutational scanning to measure how all single amino-acid mutations to G affect cell entry and neutralization by a panel of antibodies. These measurements identify sites...

Topics

Open a Topic to create a Post that cites this publication.

• Antibodies, Neutralizing
• Antibodies, Viral
• Antigens, Viral
• Glycoproteins
• Immune Evasion
• Rabies
• Rabies virus
• Viral Envelope Proteins

Identifiers and source

Literature Corpus work

47d0ec47-dddd-55c2-85c8-e9987b923bc4

DOI

10.1101/2024.12.17.628970