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Article

Deep mutational scanning reveals functional constraints and antibody-escape potential of Lassa virus glycoprotein complex.

Immunity - 10 Sept 2024

Carr Caleb R, Crawford Katharine H D, Murphy Michael, Galloway Jared G, Haddox Hugh K, Matsen Frederick A, Andersen Kristian G, King Neil P, Bloom Jesse D

Abstract excerpt

Lassa virus is estimated to cause thousands of human deaths per year, primarily due to spillovers from its natural host, Mastomys rodents. Efforts to create vaccines and antibody therapeutics must account for the evolutionary variability of the Lassa virus's glycoprotein complex (GPC), which mediates viral entry into cells and is the target of neutralizing antibodies. To map the evolutionary space accessible to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39013466
DOI: 10.1016/j.immuni.2024.06.013
PMCID: PMC11390330

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