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Article

Functional and antigenic landscape of the Nipah virus receptor-binding protein.

Cell - 1 May 2025

Larsen Brendan B, McMahon Teagan, Brown Jack T, Wang Zhaoqian, Radford Caelan E, Crowe James E, Veesler David, Bloom Jesse D

Abstract excerpt

Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here, we use deep mutational scanning to measure how all amino-acid mutations to the RBP affect cell entry, receptor binding, and escape from neutralizing antibodies. We identify functionally constrained regions of the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40132580
DOI: 10.1016/j.cell.2025.02.030
PMCID: PMC12048240

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