Article

Functional and antigenic landscape of the Nipah virus receptor binding protein

2024-04-19

Abstract excerpt

Nipah virus recurrently spills over to humans, causing fatal infections. The viral receptor-binding protein (RBP or G) attaches to host receptors and is a major target of neutralizing antibodies. Here we use deep mutational scanning to measure how all amino-acid mutations to the RBP affect cell entry, receptor binding, and escape from neutralizing antibodies. We identify functionally constrained regions of the RBP...

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Literature Corpus work: a66fc14a-cd70-57a8-8c23-671b37a79da0
DOI: 10.1101/2024.04.17.589977

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