Article

Conformational ensemble-based framework enables rapid development of Lassa virus vaccine candidates

2024-11-22

Abstract excerpt

<h4>ABSTRACT</h4> Lassa virus (LASV), an arenavirus endemic to West Africa, poses a significant public health threat due to its high pathogenicity and expanding geographic risk zone. LASV glycoprotein complex (GPC) is the only known target of neutralizing antibodies, but its inherent metastability and conformational flexibility have hindered the development of GPC-based vaccines. We employed a variant of AlphaFol...

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Literature Corpus work: 0b83d3ea-cba9-596e-9517-083e753de784
DOI: 10.1101/2024.11.21.624760

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