Clonal hematopoiesis is associated with risk of severe Covid-19.

doi:10.1038/s41467-021-26138-6

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Article

Clonal hematopoiesis is associated with risk of severe Covid-19.

Nature communications - 13 Oct 2021

Bolton Kelly L, Koh Youngil, Foote Michael B, Im Hogune, Jee Justin, Sun Choong Hyun, Safonov Anton, Ptashkin Ryan, Moon Joon Ho, Lee Ji Yeon, Jung Jongtak, Kang Chang Kyung, Song Kyoung-Ho, Choe Pyoeng Gyun, Park Wan Beom, Kim Hong Bin, Oh Myoung-Don, Song Han, Kim Sugyeong, Patel Minal, Derkach Andriy, Gedvilaite Erika, Tkachuk Kaitlyn A, Wiley Brian J, Chan Ireaneus C, Braunstein Lior Z, Gao Teng, Papaemmanuil Elli, Esther Babady N, Pessin Melissa S, Kamboj Mini, Diaz Luis A, Ladanyi Marc, Rauh Michael J, Natarajan Pradeep, Machiela Mitchell J, Awadalla Philip, Joseph Vijai, Offit Kenneth, Norton Larry, Berger Michael F, Levine Ross L, Kim Eu Suk, Kim Nam Joong, Zehir Ahmet

Abstract excerpt

Acquired somatic mutations in hematopoietic stem and progenitor cells (clonal hematopoiesis or CH) are associated with advanced age, increased risk of cardiovascular and malignant diseases, and decreased overall survival. These adverse sequelae may be mediated by altered inflammatory profiles observed in patients with CH. A pro-inflammatory immunologic profile is also associated with worse outcomes of certain...

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PMID: 34645798
DOI: 10.1038/s41467-021-26138-6
PMCID: PMC8514469

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