Article

<i>In situ</i> characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampus

2020-06-22

Abstract excerpt

Astrocytes govern critical aspects of brain function via Ca 2+ signals, the majority of which associate with mitochondria. However, little is known with regard to in situ sources, kinetics or mechanisms of Ca 2+ influx in astrocytic mitochondria. To address this knowledge gap, we expressed the genetically encoded calcium indicator, GCaMP6f within the mitochondrial matrix of adult mouse astrocytes in the dorsola...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2f389770-ef7f-568a-ba4b-71a859b464e8
DOI: 10.1101/2020.06.21.163618

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

<i>In situ</i> characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusDOI 10.1101/2020.06.21.163618Read

In situ characterization of calcium fluxes in astrocytic mitochondria from the mouse striatum and hippocampusSemantic proximity Read

Mitochondria at the SynapseSemantic proximity Read

Insights into calcium signaling and gene expression in astrocytes uncovered with 129S4 Slc1a3-2A-CreERT2 knock-in miceSemantic proximity Read

Severe disturbance in the Ca2+ signaling in astrocytes from mouse models of human infantile neuroaxonal dystrophy with mutated Pla2g6.Semantic proximity Read

Norepinephrine regulates Ca <sup>2+</sup> signals and fate of oligodendrocyte progenitor cells in the cortexSemantic proximity Read

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?Semantic proximity Read

Compartment-specific analysis reveals disrupted astrocytic calcium transients in Alzheimer's miceSemantic proximity Read

Ca <sup>2+</sup> signaling in astrocytes is sleep-wake state specific and modulates sleepSemantic proximity Read

Neuronal activity inhibits axonal mitochondrial transport in a region-specific mannerSemantic proximity Read

IPSC-derived midbrain astrocytes from Parkinson’s disease patients carrying pathogenic <i>SNCA</i> mutations exhibit alpha-synuclein aggregation, mitochondrial fragmentation and excess calcium releaseSemantic proximity Read

Wide-Field Calcium and Flavoprotein Autofluorescence Imaging in Living MiceSemantic proximity Read

Store-Operated Ca <sup>2+</sup> Channels Mediate Microdomain Ca <sup>2+</sup> Signals and Amplify Gq-Coupled Ca <sup>2+</sup> Elevations in Capillary PericytesSemantic proximity Read