Article

Distinct Ca <sup>2+</sup> signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammation

2025-05-16

Abstract excerpt

The leptomeninges, composed of the arachnoid mater, and pia mater, contains distinct subgroups of fibroblasts that differ in location and transcriptomic profiles. These fibroblasts contribute to the blood–cerebrospinal fluid barrier under physiological conditions, participate in fibrosis, and support blood–brain barrier integrity during injury and disease. However, their Ca 2+ signaling profiles and underlying me...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c3808dd-cca7-566c-b773-06af7e69e0de
DOI: 10.1101/2025.05.13.653681

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Distinct Ca <sup>2+</sup> signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationDOI 10.1101/2025.05.13.653681Read

Distinct Ca2+ signatures of leptomeningeal fibroblast subgroups in awake mouse brains in health and inflammationSemantic proximity Read

Piezo1 in microglial cells: Implications for neuroinflammation and tumorigenesisSemantic proximity Read

Isolation and <i>in vitro</i> culture of primary <i>pia mater</i> cellsSemantic proximity Read

Microglia contribute to neuronal synchrony despite endogenous ATP-related phenotypic transformation in acute mouse brain slices.Semantic proximity Read

Microglial amyloid beta clearance is driven by PIEZO1 channelsSemantic proximity Read

Norepinephrine regulates Ca <sup>2+</sup> signals and fate of oligodendrocyte progenitor cells in the cortexSemantic proximity Read

Microglial Calcium Signaling is Attuned to Neuronal ActivitySemantic proximity Read

Disrupted calcium dynamics in reactive astrocytes occur with endfeet-arteriole decoupling in an amyloid mouse model of Alzheimer’s diseaseSemantic proximity Read

Neuroinflammation in an optimized model of lysophosphatidic acid (LPA)-induced post-hemorrhagic hydrocephalusSemantic proximity Read

Mechanobiological Specialization of Choroid Plexus Macrophages Defined by Titin ExpressionSemantic proximity Read

Multi-modal choroid plexus pathology in aging and Alzheimer’s diseaseSemantic proximity Read

A high-content platform for physiological profiling and unbiased classification of individual neuronsSemantic proximity Read