Endothelial Arf6 sustains capillary electrical signaling and cerebral blood flow through PIP ₂ regeneration and activation of Kir2.1 channels

Abstract excerpt

Brain capillaries sense neural activity and direct blood flow to active regions—a process termed neurovascular coupling that underlies activity-dependent increases in local perfusion (functional hyperemia). A key contributor to functional hyperemic responses is the capillary endothelial cell (cEC) inward rectifier K + (Kir2.1) channel, which is activated by neuronal activity-derived extracellular K + and initiat...

Topics

Open a Topic to create a Post that cites this publication.

• Apoptosis Regulatory Proteins
• Endothelial Cells
• Hemangioma, Cavernous, Central Nervous System
• Intracerebral and Subarachnoid Hemorrhage Research
• Intracranial Aneurysms: Treatment and Complications
• KRIT1 Protein
• Mutation
• Vascular Malformations Diagnosis and Treatment

Identifiers and source

Literature Corpus work

2331a952-df4e-5b40-b448-0da7f3c42e43

DOI

10.64898/2025.12.23.696233