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Article

Knockdown of BACE1‐AS Nonprotein‐Coding Transcript Modulates Beta‐Amyloid‐Related Hippocampal Neurogenesis

1 Jan 2011

Abstract excerpt

Background. Alzheimer's disease (AD) is a devastating neurological disorder and the main cause of dementia in the elderly population worldwide. Adult neurogenesis appears to be upregulated very early in AD pathogenesis in response to some specific aggregates of beta-amyloid (Aβ) peptides, exhausting the neuronal stem cell pools in the brain. Previously, we characterized a conserved nonprotein-coding antisense...

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PMID: 21785702
DOI: 10.4061/2011/929042

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