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Article

HPF1 dynamically controls the PARP1/2 balance between initiating and elongating ADP-ribose modifications.

Nature communications - 18 Nov 2021

Langelier Marie-France, Billur Ramya, Sverzhinsky Aleksandr, Black Ben E, Pascal John M

Abstract excerpt

PARP1 and PARP2 produce poly(ADP-ribose) in response to DNA breaks. HPF1 regulates PARP1/2 catalytic output, most notably permitting serine modification with ADP-ribose. However, PARP1 is substantially more abundant in cells than HPF1, challenging whether HPF1 can pervasively modulate PARP1. Here, we show biochemically that HPF1 efficiently regulates PARP1/2 catalytic output at sub-stoichiometric ratios matching...

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Identifiers

PMID: 34795260
DOI: 10.1038/s41467-021-27043-8
PMCID: PMC8602370

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